Research update

Published on Friday, January 12, 2024

The Research Division within the Department of Obstetrics and Gynecology (OB-GYN) is currently maintaining and developing a multitude of research projects ranging from clinical trials, educational research, retrospective chart reviews, and basic science projects. One project to highlight is the TOLAC Study (Trial of Labor After Cesarean Section), which is a retrospective chart review led by our clinical faculty and residents. This study enrolled 745 women over a span of 5 years.

TOLAC refers to a planned attempt of vaginal delivery in women who have previously undergone 1 prior cesarean delivery. A successful TOLAC is known as a vaginal birth after cesarean (VBAC). VBAC is associated with decreased maternal and neonatal morbidity as well as decreased complications in future pregnancies. The primary objective of this study was to determine success and complication rates of those undergoing a TOLAC and determine factors that can aid in predicting a successful VBAC.

In this study, we noted a 73% success rate in women attempting VBAC at the University of Mississippi Medical Center (UMMC). Of note, Black women were the least likely to have a successful VBAC compared to White and Asian counterparts. Additionally, increased body mass index (BMI) also reduced the chances of VBAC success, and BMI was elevated in Black women.  This study highlights racial disparities in our patient population and the need to understand and implement care specific to patients’ needs.

Beyond TOLAC, UMMC OB-GYN research performs variety of OB-GYN related research including cancer, quality improvement projects, prenatal and postnatal cardiovascular risk, health disparities, diabetes, and obesity research. In the summer of 2023, the research team, in collaboration with the pediatrics gastrointestinal team, will implement a clinical trial to assess the use of a vaginal secretion made into a pellet for neonatal consumption to improve the neonatal microbiome in babies born by cesarean section.